#Dmg supplement for horses back full#
Due to the fact that PSSM is a genetic condition, there can be no ‘cure’ in the symptomatic horse, but many affected horses can be restored to full health and work status. Anecdotal evidence also suggests that the anti-inflammatory/antioxidant Dimethylglycine (DMG) may be beneficial for horses with muscle disorders like PSSM.īeth Valentine, DVM, proposed the first successful therapy to halt and reverse the progression of PSSM, except in advanced cases.
Other antioxidants include vitamin C, Grape Seed Extract and Super Oxide Dismutase.
#Dmg supplement for horses back free#
What is safe to feed my horse?īecause of the oxidative stress associated with this disorder, as well as the free radicals generated from the high-fat diet often required by horses with PSSM, experts recommend supplementing with vitamin E for its antioxidant properties. When altering both diet and exercise, 90% of horses have had no or few episodes of tying-up. If only the diet changes, it has been found that approximately 50% of horses improve. This enhances glucose utilization and improves energy metabolism in skeletal muscle. An important part of the management of PSSM horses is daily exercise. That is why horses suffering from PSSM should avoid them and intake of extra calories can come from fats. At present, there is not a specific genetic test for Type 2 PSSM and we do not have conclusive evidence that it is inherited.Ĭarbohydrates that are high in starch, such as sweet feed, corn, wheat, oats, barley, and molasses, appear to exacerbate Type 1 and Type 2 PSSM. Horses with Type 2 PSSM lack the mutation that is specific for Type 1 PSSM. Both types have an abnormal type of glycogen staining in muscle biopsies, and Type 1 is findable through genetic testing. The cause of Type 2 PSSM is not yet identified. The mutation causing PSSM is a point mutation on the GYS1 gene which codes for the skeletal muscle form of the glycogen synthase enzyme. Type 1 PSSM is a result of a mutation in the GYS1 gene.
The two forms of PSSM are both the result of the accumulation of muscle glycogen which is the storage form of glucose in muscles. Tying-up associates with polysaccharide accumulation in muscle effects in thousands of horses. The abnormal accumulation of the normal form of sugar stored in muscle (glycogen), as well as an abnormal form of sugar (polysaccharide) in muscle tissue, characterizes Polysaccharide storage myopathy (PSSM). Some weanlings and yearlings, particularly those with type 2 PSSM can develop muscle stiffness with daily activities and have extreme difficulty rising. This occurs more often if they have a concurrent infection such as pneumonia or diarrhea. Very young foals with PSSM occasionally show signs of severe muscle pain and weakness. When this happens it is a very serious situation, as it can damage the horse’s kidneys if they become dehydrated. This is due to muscle proteins being released into the bloodstream and passed into the urine. The urine in such horses can be coffee-colored. This can result in the horses being unable to stand and being uncomfortable even when lying down. Rarely, episodes of muscle pain and stiffness can be quite severe. Mildly affected horses, however, may have only one or two episodes/year. Most horses with PSSM have a history of numerous episodes of muscle stiffness at the commencement of training. Some horses will try pawing and rolling immediately after exercise. They are painful, stiff, sweat profusely, and have firm hard muscles, particularly over their hindquarters. When horses stop moving they may stretch out as if to urinate. PSSM Episodesĭuring an episode, horses seem lazy, have a shifting lameness, tense up their abdomen, and develop tremors in their flank area. However, horses affected with PSSM can exhibit symptoms even without exercise. The episodes usually begin after very light exercise such as 10-20 minutes of walking and trotting. A correlation to when they receive little active turn-out. The signs are most often seen in horses when they are put into initial training or after a lay-up period. Horses with both forms of PSSM have signs typically associated with tying-up such as muscle stiffness, sweating, and reluctance to move.
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